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Is the 2-h Sample Really Necessary in the Oral Glucose Tolerance Test in Pregnant Females?

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To the Editor:

We read with interest the recent article by Daly et al. on the impact of implementing preanalytical laboratory standards on the diagnosis of gestational diabetes mellitus and found the comment “efficiencies may be achieved by omitting the 2-h OGGT sample” (1) especially interesting because our laboratory performs approximately 5000 oral glucose tolerance tests (OGTT)1 annually on pregnant females, and the elimination of the 2-h sample would increase patient safety and convenience by elimination of superfluous phlebotomy and reduction in waiting room time.

To evaluate this potential efficiency, 75-g OGTT tests were performed following a positive 50-g gestational diabetes screen and patients were asked to fast for a minimum of 8 h before performing the OGTT. Samples were collected in …

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